The exact cause of IBD isn't
While the cause is unknown, inflammatory bowel disease is known to involve an interaction between genes, the immune system, and environmental factors.
It is the complex interaction between these 3 factors that is believed to result in the inflammation found in Crohn’s disease and ulcerative colitis.
An overactive immune system may produce inflammation.
The gastrointestinal (GI) tract normally contains harmless bacteria, many of which may aid in digestion.
In people with IBD, these bacteria may be mistaken for harmful invaders and the immune system responds by producing inflammation. If the inflammation doesn’t subside, it may lead to chronic inflammation, ulceration, and thickening of the intestinal wall.
The role of genetics and environmental factors in IBD.
This abnormal immune system reaction usually occurs in people who have inherited genes that make them susceptible to IBD.
Unidentified environmental factors may then trigger a harmful immune response in the intestines, resulting in inflammation and the IBD symptoms associated with IBD.
Did you know?
IBDs involve an
interaction between genes,
the immune system, and
In people who have
factors may trigger a
harmful immune response
in the intestines.